兼具成骨和抗感染性能的醫(yī)用金屬材料研究進展

兼具成骨和抗感染性能的醫(yī)用金屬材料研究進展Advances in Metallic Biomaterials with both Osteogenic and Anti-infection Properties

材料的成骨性能（即材料表面或周圍促進新骨生成的性能）一直以來是大部分骨科植入性醫(yī)療器械的首要臨床要求。近年來，材料的抗感染或者抗菌性能（尤其是不依賴抗生素的抗感染或者抗菌性能）逐漸成為骨科植入物的另一重要臨床要求。因此，開發(fā)同時具有成骨和抗感染能力的生物材料對于骨科臨床具有重要意義。醫(yī)用金屬材料在骨科植入物中占有重要地位，但兼具這兩種性能的金屬材料在以往的臨床實踐或基礎研究中都極為少見，最近才得以廣泛研究。本綜述將介紹同時具有成骨和抗感染性能的新型醫(yī)用金屬材料的研究進展，首先介紹相關金屬材料以及金屬材料表面改性的研究成果，然后對材料兼具成骨和抗感染的機理進行分析討論，最后提出此類新型醫(yī)用金屬材料的研究展望。

Osteogenic capacity (i.e., properties that promote new bone formation around the implant) has long been a clinical requirement for most orthopedic implants. Recently, anti-infection or antibacterial property has increasingly become critical for orthopedic implants (especially without the use of antibiotics). Orthopedic implant materials with simultaneous osteogenic and anti-infection capacities are extremely promising for orthopedic applications, but such materials are not widely available to date and have only recently been researched. In this review article, the advances in metallic biomaterials with both osteogenic and anti-infection capacities were introduced in the review considering of the widely application of metallic biomaterials in orthopedics. Firstly, numerous attractive metal formulations that exhibit both osteogenic and anti-infection capacities as well as surface modification strategies that enhance such capacities are introduced. Secondly, several possible mechanisms underlying the osteogenic and anti-infection properties are discussed. Finally, an outlook of this field was proposed.

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