Ti6Al4V表面生物功能純Mg薄膜制備及性能研究

Ti6Al4V表面生物功能純Mg薄膜制備及性能研究Preparation and Properties of Biological Functional Magnesium Coating on Ti6Al4V

本研究利用多弧離子鍍技術(shù)在Ti6Al4V表面沉積純Mg薄膜，研究了不同工作氣壓對(duì)純Mg薄膜表面質(zhì)量及性能的影響，研究了純Mg薄膜的體外降解等性能、抗菌性及生物安全性能。結(jié)果表明：多弧離子鍍方法可將純Mg薄膜制備于鈦合金表面，薄膜顆粒均勻致密，未見明顯缺陷。體外浸泡實(shí)驗(yàn)結(jié)果表明:由于Ti6Al4V與Mg發(fā)生電偶腐蝕而使Mg薄膜迅速降解，1周時(shí)間內(nèi)薄膜基本降解完畢?？咕鷮?shí)驗(yàn)結(jié)果表明:純Mg薄膜樣品對(duì)金黃色葡萄球菌具有強(qiáng)烈的殺滅作用，表現(xiàn)出良好的抗細(xì)菌感染功能。細(xì)胞毒性實(shí)驗(yàn)結(jié)果表明:純Mg薄膜可促進(jìn)骨髓間充質(zhì)干細(xì)胞（rBMSCs）的增殖。

Currently, metallic biomaterials used in orthopedics are normally bioinert which is hard to integrate with the bone tissue inducing aseptic loosening and easy to get infection, which is the main reason of implantation failure. Mg based metals are considered to be a new generation of revolutionary metallic biomaterials due to its similar density and mechanical properties with natural bone, good biocompatibility, degradability in the body as well as the biological functional ability to promote new bone tissue formation. In addition, the degradation of magnesium may increase the local pH which can inhibit the growth of bacteria.In this work, pure Mg coating was deposited on Ti6Al4V substrate by arc ion plating. The effects of different working pressures on the surface quality and properties of Mg coating were investigated. The degradation, antibacterial and biosafety properties were study. The results showed that the pure Mg coating can be deposited on the surface of Ti6Al4V substrate and the coating was uniform and smooth. The immersion test in vitro showed that the degradation was very fast because of galvanic corrosion, and the whole process was finished in about one week. The results of antimicrobial experiments showed that the Mg coating can kill staphylococcus aureus and showed good antibacterial function. The results of cytotoxicity test showed that Mg coating promoted rabbit bone marrow mesenchymal stem cells (rBMSCs) growth and proliferation.

全文下載：https://pan.baidu.com/s/1kUNUCEb