鎂合金全降解血管支架研究進展

鎂合金全降解血管支架研究進展Research Progress of Bioresorbable Magnesium Scaffolds

全降解血管支架具有克服傳統(tǒng)不可降解金屬支架長期植入引起的慢性炎癥、晚期支架血栓以及需長期服用抗血小板藥物等問題的潛在優(yōu)勢，因此目前在世界范圍內(nèi)是介入醫(yī)學(xué)工程領(lǐng)域研究開發(fā)的熱點。鎂合金全降解血管支架因兼具較高的支撐強度和生物可降解吸收兩種特性，更是走在了全降解血管支架發(fā)展的前列。本文主要介紹國際上廣泛關(guān)注的德國Biotronik公司鎂合金全降解血管支架的研發(fā)歷程，以及我國自主研發(fā)的JDBM、MgZnYNd兩種鎂合金全降解血管支架研發(fā)現(xiàn)狀。國內(nèi)外大量的動物和臨床試驗表明，鎂合金血管支架在體內(nèi)是安全有效的，然而其降解速度比預(yù)期稍快。不過，隨著研究的進一步深入，通過建立新型合金體系并改善支架的結(jié)構(gòu)和涂層，我們有理由相信鎂合金全降解血管支架性能將逐漸完善，并在不久的將來在治療心血管疾病等方面發(fā)揮其重大作用。

Because the bioresorbable scaffold (BRS) could overcome the difficulties caused by traditional nondegradable stents including chronic inflammation, late stent thrombosis, and long-term antiplatelet therapy, BRS is the research focus of interventional medical engineering. Because of both the high supporting strength and bioresorbable feature, the bioresorbable magnesium scaffold (BMS) is the research focus of BRS. In this paper, development process of Biotronik serial magnesium stents along with research progress of our domestic JDBM and MgZnYNd stents is reviewed. According to the results of extensive in vitro and in vivo studies, BMS is safe and effective in vivo although its degradation rate is faster than our expectation. Through developing novel alloy system and improving stents’ structure, we believe the performance of BMS will be more better and it will play more important role on the therapy of cardiovascular disease.

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